Pharmacologic Management of Tumor Lysis Syndrome in Adults

Introduction Tumor lysis syndrome (TLS) constitutes the most frequent oncologic emergency. It is developed by lysis of tumor cells, during or within 7 days of chemotherapy. The output of large amounts of potassium, phosphate, and nucleic acid, can result in characteristic electrolyte disturbances and cause the characteristic life-threatening arrhythmias (from electrolyte imbalances) and AKI (from […]

Management of Hypokalemia in Cardiac Arrest

Download PDF Introduction Severe hypokalemia may precipitate profound and life-threatening cardiac complications including arrhythmia and asystole. Classical teaching is that in cardiac arrest with non-shockable rhythms the management include to identify and treat the H’s & T’s which include hyper and hypokalemia. Potassium chloride is the therapy of choice, however, the dose and administration of […]

Penicillin Allergy & Cross-Reactivity

Introduction Only 0.5% to 2% of patients with a documented penicillin allergy that are administered a penicillin will exhibit a hypersensitivity reaction, usually presenting as a rash or hives. True IgE-mediated penicillin allergies that cause anaphylaxis are rare. An IgE-mediated penicillin allergy can diminish over time, as 80% of patients become tolerant after a decade. […]