Concomitant Parenteral Benzodiazepines and Olanzapine

Introduction Intramuscular olanzapine and parenteral benzodiazepines are commonly used agents in the ED for acute agitation. An FDA warning states that potentially fatal respiratory depression can occur when olanzapine and parenteral benzodiazepines are administered concomitantly stating “concomitant administration of intramuscular olanzapine and parenteral benzodiazepine has not been studied and is therefore not recommended.” This warning […]