High-Dose Insulin Euglycemic Therapy in Calcium Channel Blocker and Beta-Blocker Toxicity

Author: Nicole Frost, PharmD Introduction Medications that work on the cardiovascular system are common cause of poisoning and account for a large number of deaths from overdoses each year. Calcium channel blocker toxicity inhibits insulin secretion resulting in hyperglycemia and alteration of myocardial function. Beta-blocker poisoning can cause impaired insulin release, therefore increasing glycogenolysis and […]

Airway Series: Post-Intubation Sedation

Introduction Rapid sequence intubation (RSI) is a process whereby an induction agent and a neuromuscular blocking agent are given in rapid succession to facilitate endotracheal intubation  The immediate post intubation period in the ED is a critical time for continued patient stabilization.  While physical adjuncts like securing the tube, in line suctioning, and elevating the […]

Airway Series: Paralyzing Agents

Introduction Rapid sequence intubation (RSI) is a process whereby an induction agent and a neuromuscular blocking agent are given in rapid succession to facilitate endotracheal intubation The selection of a specific sedative depends on multiple factors: the clinical scenario, which includes patient factors (includes cardiorespiratory and neurologic status, allergies, comorbidity) and the clinician’s experience/training and […]