Paralytics in Myasthenia Gravis

Introduction Myasthenia Gravis (MG), an autoimmune disorder is the most common primary disorder of neuromuscular transmission MG results from the destruction of post-synaptic nicotinic acetylcholine (ACh) receptors located at the neuromuscular junction MG causes significant complications including myasthenic crisis, an acute respiratory paralysis requiring intensive care (e.g. mechanical ventilation) The decreased amount of Ach causes […]

Airway Series: Paralyzing Agents

Introduction Rapid sequence intubation (RSI) is a process whereby an induction agent and a neuromuscular blocking agent are given in rapid succession to facilitate endotracheal intubation The selection of a specific sedative depends on multiple factors: the clinical scenario, which includes patient factors (includes cardiorespiratory and neurologic status, allergies, comorbidity) and the clinician’s experience/training and […]

Steroid Use in ARDS With and Without COVID-19

Introduction Steroid use in ARDS has been a highly debated topic around dosing, which steroid, durations, when to initiate therapy. With the emergence of COVID-19, the debate has resurfaced along with numerous trials. The thought behind using steroids in this patient population is to use the anti-inflammatory and anti-proliferative effects of glucocorticoids to mitigate the […]