Cannabinoid Hyperemesis Syndrome (CHS)

Introduction¬† 1. Commonly identified as symptoms, including nausea, cyclic vomiting and abdominal pain, that are refractory  to available antiemetics and analgesics.   2. Patients tend to take compulsive hot baths/showers for symptom relief.  3. Characteristically distinguished from cyclic vomiting syndrome, these symptoms are usually preceded by years  of chronic cannabis use and symptoms are typically resolved […]

The Use of Phenylephrine for Management of Priapism

Download the PDF Introduction The American Urological Association (AUA) defines priapism as a persistent penile erection lasting at least four hours related or non-related to sexual stimulation.¬† Priapism is a medical emergency that is rare, unpredictable and can occur in all age groups especially in patients with sickle cell disease. A sympathomimetic medication such as […]

Epinephrine, anaphylaxis, and biphasic reactions

Introduction Anaphylaxis is a life-threatening, IgE-mediated allergic reaction most commonly triggered by medications, foods, and stinging insects. Symptoms occur rapidly, within minutes up to as late as 1 hour, and can involve urticaria, angioedema, dyspnea, hypotension, nausea/vomiting, and abdominal pain among many other reactions. Some patients experience biphasic anaphylaxis, which is recurrent anaphylaxis that occurs […]

Hereditary Angioedema (HAE)

Introduction HAE results from a deficiency in quantity or function of C1 inhibitor (C1-INH) due to a genetic defect A rare, autosomal-dominant disorder that manifests in early childhood  Swelling in HAE results from excess bradykinin production, which is a potent vasodilatory mediator  Histamine and other mast cell mediators are not directly involved  HAE attacks are […]